5-氮雜-2′-脫氧胞苷
5-氮雜-2′-脫氧胞苷
性質
related categories an-az,approved therapeutics/drug candidates,bioactive small molecule alphabetical index,eisai,fluorination ready pharma-developed compounds,
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inchi key xaudjqyhkzqpeu-kvqbguixsa-n
assay ≥97%
solubility acetic acid: water (1:1): 50mg/ml
originator eisai
產品描述
包裝
5, 10 mg in glass bottle
50 mg in glass insert
application
5-aza-2′-deoxycytidine has been used as a demethylating agent in breast cancer cell line, chromatin, dna and promoter region of p16 gene.[3][4][5][6]
biochem/physiol actions
5′-脫氧雜氮胞苷可引起dna去甲基化或半去甲基化。dna去甲基化可通過隨著提高的核酸酶活性而“打開”染色質的結構來調控基因的表達。這種染色質結構的重塑可實現轉錄因子與啟動子區(qū)域的結合、轉錄復合物的組裝及基因表達。
features and benefits
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該化合物由eisai開發(fā)。
5-aza-2′-deoxycytidine is a dna-hypomethylating agent, which stimulates differentiation and apoptosis of leukemic cells.[1]it is a 2′-deoxycytidine analogue.[2]5-aza-2′-deoxycytidine is used to treat chronic myelomonocytic leukemia, refractory anemia, myelodysplastic syndrome and acute myeloid leukemia.