mouseanti-tnni3k
from:abcam
catalognumber:rs-9458r
quantitysize:100ul(dilutewithph7.40.01mpbsorantibodydiluent)
background:
tnni3k,alsoknownascark,isa936aminoacidserine/threonine-proteinkinasethatishighlyexpressedinheart.overexpressionoftnni3kleadstoimprovedcardiacfunctionbyenhancingbeatingfrequencyandincreasingcontractileforceandepinephrineresponse.tnni3ksuppressesphosphorylationofcardiactroponiniandp38/jnk-mediatedapoptosis,thereforeprotectingthemyocardiumfromischemicinjury.administrationoftnni3ktomicewithmyocardialinfarctionimprovescardiacperformanceandattentuatesventricularremodeling,suggestingthattnni3kcouldbeapromisingtargetinthetreatmentofcardiacdiseases.therearefourisoformsoftnni3kthatareproducedasaresultofalternativesplicingevents.
function:
mayplayaroleincardiacphysiology.
subunit:
interactswithtnni3,actc,acta1,mybpc3,aip,babp3andhadhb
specificity:anti-tnni3kisamousemonoclonalantibody
specificforanti-tnni3kofhuman,mouse,rat,
-useforwesternblotting,elisa,immunoprecipitationandimmunohistochemistry
proteingaffinitychromatographypurification,purity:>95%isotype:iggmolwt:93kda
application:
wb=1:100-500elisa=1:500-1000ihc-p=1:100-500ihc-f=1:100-500optimaldilutions/concentrationsshouldbedeterminedbytheenduser..klhconjugatedsyntheticpeptidederivedfromhumantnni3k
storage:storeat-20℃foroneyear.avoidrepeatedfreeze/thawcycles.thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20℃.whenreconstitutedinsterileph7.40.01mpbsordiluentofantibody,theantibodyisstableforatleastsixweeksat2-4℃
importantnote:thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.